Palladium Catalyzed Asymmetric C(sp)-P Cross-Coupling via Kinetic Resolution of Secondary Phosphine Oxides.

Herein, we report a palladium-catalyzed asymmetric C(sp)-P cross-coupling reaction between secondary phosphine oxides (SPOs) and alkynyl chlorides, providing a direct and efficient route to access P-stereogenic alkynyl phosphine oxides via a kinetic resolution process. This method proceeds under mild conditions, delivering products with excellent enantioselectivity (up to 94% ee) and good functional group tolerance. This work offers a straightforward and modular strategy for the synthesis of valuable chiral alkynyl phosphorus compounds.