Effect of estrogen treatment for one year on carbohydrate and lipid metabolism in women with normal and abnormal glucose tolerance test results. Glucose, insulin, growth hormone, triglycerides, and Premarin.

A prospective study of the effects of a conjugated estrogen (Premarin, 1.25 mg.) was performed in 36 women over a 1 year period. Each subject received a 3 hour oral glucose tolerance test before starting the medication and another after 1 year of use. The blood glucose levels were similar at five times during the two tests except for a significant elevation of the 1 hour value at the 1 year test. There were no changes in the plasma insulin, growth hormone, or fasting triglyceride levels. These results suggest that the cyclic administration of this estrogen does not alter lipid or carbohydrate metabolism.