A 15-year Follow-up of Persistent Pulmonary Lesions after Silicone Removal in a Patient with Silicon-induced Autoimmune/Inflammatory Syndrome.

A 65-year-old woman with a history of silicone breast implantation was admitted to our hospital with abnormal chest shadows. Although the implants had already been removed, chest CT revealed diffuse ground-glass opacities in both lungs. Thoracoscopic lung biopsy revealed non-necrotizing epithelioid granulomas and silica-phagocytic macrophages, leading to a diagnosis of silicone-implant-associated autoimmune/inflammatory syndrome induced by adjuvants (ASIA). Over a follow-up period of more than 15 years without treatment, the ground-glass opacities improved only slightly. We herein present the longest follow-up chest CT findings of silicone implant-associated ASIA.