Ginekologia polska · 2004
[Effect of long-term therapy with transdermal patches releasing glyceryl trinitrate (GTN) used in pregnant hypertensive women on stabilisation of blood pressure and on the condition of the newborn infant].
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Brzozowska Maria, Kowalska-Koprek Urszula, Karowicz-Bilińska Agata, Pajszczyk-Kieszkiewicz Teresa
Аннотация
OBJECTIVE: An observation of an influence of long-term therapy of pregnant women affected by arterial hypertension with transdermal patches releasing GTN on stabilisation of blood pressure and newborn condition.
STUDY DESIGN: The transdermal patches (Minitran S10) releasing GTN were used for the treatment of 27 pregnancies between 27-34 weeks admitted for hypertension above 150/100 mmHg. The average period of obtaining the proper blood pressure values, time of therapy, side effects of treatment and effects of nitrate tolerance were assessed. After delivery the newborns condition were estimated by Apgar score and their trophy was assessed after the centile chart.
RESULTS: The diminishing of mean blood pressure values in range 135/85 mmHg was received after 8 to 48 hours of treatment in 25 of the examined women. The time of therapy was from 3 to 13 weeks without any serious side effects besides transient headaches eliminated by application of oral analgesic drugs. 24 newborns were delivered in good conditions--8-9 Apgar score. No side effects of long-term therapy with patches releasing GTN were observed among the newborns.
CONCLUSIONS: The long-term transdermal treatment afford possibilities for pregnancy prolongation until the term of delivery and improves the foetal development conditions. The side effects of treatment are transient and affected only mothers.
STUDY DESIGN: The transdermal patches (Minitran S10) releasing GTN were used for the treatment of 27 pregnancies between 27-34 weeks admitted for hypertension above 150/100 mmHg. The average period of obtaining the proper blood pressure values, time of therapy, side effects of treatment and effects of nitrate tolerance were assessed. After delivery the newborns condition were estimated by Apgar score and their trophy was assessed after the centile chart.
RESULTS: The diminishing of mean blood pressure values in range 135/85 mmHg was received after 8 to 48 hours of treatment in 25 of the examined women. The time of therapy was from 3 to 13 weeks without any serious side effects besides transient headaches eliminated by application of oral analgesic drugs. 24 newborns were delivered in good conditions--8-9 Apgar score. No side effects of long-term therapy with patches releasing GTN were observed among the newborns.
CONCLUSIONS: The long-term transdermal treatment afford possibilities for pregnancy prolongation until the term of delivery and improves the foetal development conditions. The side effects of treatment are transient and affected only mothers.