Neuron-Specific Enolase as a Biological Marker for Welders' Pneumoconiosis.

OBJECTIVE

The aim of the study is to investigate the relationship between serum neuron-specific enolase (NSE) and welders' pneumoconiosis, through chest x-ray and serum NSE.

METHODS

The exposed group included 37 welders. The nonexposed group included 38 administrative workers. Both groups underwent history taking, clinical examination, chest x-ray, serum chromium, and serum neuron-specific enolase. Air sampling was done for total suspended particles, respirable particles, and welding fumes.

RESULTS

All the air samples were within the national threshold limit values. Chest x-ray abnormalities were found in eight welders (21.6%), and included reticular opacities, scattered nodules or ground-glass opacities. Serum chromium and NSE were significantly higher among welders. Serum NSE correlated positively with the duration of exposure and serum chromium level among welders.

CONCLUSIONS

Serum NSE can be used as a biomarker for early detection of welders' pneumoconiosis.