The Pan African medical journal · 2025
Investigation of the relationship between uterine artery Doppler diastolic notching and serum apelin-13 and apelin-36 concentrations between the 11th and 14th weeks of pregnancy: a case-control study.
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Acar Fethiye Demirtaş, Kale İbrahim, Muhcu Murat
Аннотация
INTRODUCTION: the apelin family plays a role in the proliferation and migration of trophoblasts. Based on this, we aimed to investigate the relationship between diastolic notching in uterine artery Doppler and serum apelin-13 and apelin-36 concentrations between 11 and 14 weeks of gestation.
METHODS: forty-four (44) pregnant women with diastolic notching in uterine artery Doppler and 44 without diastolic notching were compared in terms of serum apelin-13 and apelin-36 concentrations.
RESULTS: the two groups were similar in terms of demographic characteristics (p > 0.05). The median apelin-13 concentration was found to be 45.4 pg/mL in the uterine artery notch-positive group, while it was 41.02 pg/mL in the uterine artery notch-negative group (p = 0.770). The median apelin-36 concentration was 546.06 pg/mL in the uterine artery notch-positive group, while it was 536.6 pg/mL in the uterine artery notch-negative group (p = 0.570). Participants were regrouped as high or normal pulsatility index (PI) according to uterine artery PI, and both groups were compared in terms of apelin-13 and apelin-36 concentrations. Median serum apelin-13 and apelin-36 concentrations were also similar in the high and normal uterine artery PI groups (p = 0.445, p = 0.402, respectively).
CONCLUSION: although the number of participants was too small to draw a definitive conclusion, no significant relationship between diastolic notching or increased resistance in the uterine artery and serum apelin-13 and apelin-36 concentrations could be detected.
METHODS: forty-four (44) pregnant women with diastolic notching in uterine artery Doppler and 44 without diastolic notching were compared in terms of serum apelin-13 and apelin-36 concentrations.
RESULTS: the two groups were similar in terms of demographic characteristics (p > 0.05). The median apelin-13 concentration was found to be 45.4 pg/mL in the uterine artery notch-positive group, while it was 41.02 pg/mL in the uterine artery notch-negative group (p = 0.770). The median apelin-36 concentration was 546.06 pg/mL in the uterine artery notch-positive group, while it was 536.6 pg/mL in the uterine artery notch-negative group (p = 0.570). Participants were regrouped as high or normal pulsatility index (PI) according to uterine artery PI, and both groups were compared in terms of apelin-13 and apelin-36 concentrations. Median serum apelin-13 and apelin-36 concentrations were also similar in the high and normal uterine artery PI groups (p = 0.445, p = 0.402, respectively).
CONCLUSION: although the number of participants was too small to draw a definitive conclusion, no significant relationship between diastolic notching or increased resistance in the uterine artery and serum apelin-13 and apelin-36 concentrations could be detected.