The regulatory mechanisms and translational applications of non-coding RNA in SARS-CoV-2 infection-related cardiovascular pathology.

SARS-CoV-2 infection not only leads to severe respiratory diseases but also has a significant impact on the cardiovascular system, inducing acute cardiac injury and various long-term cardiovascular complications. Non-coding RNAs (ncRNAs), as key molecules in gene expression regulation, exhibit important regulatory roles in viral infections and cardiovascular pathological processes. Current research indicates that ncRNAs such as miRNA, lncRNA, and circRNA participate in the occurrence and development of cardiac injury related to SARS-CoV-2 infection by regulating apoptosis, metabolic reprogramming, and cell communication. However, there are still many challenges and unresolved mysteries regarding their specific regulatory networks and clinical applications. This review systematically summarizes the expression changes and functional characteristics of ncRNAs in COVID-19-related cardiovascular diseases, focusing on their potential as biomarkers and therapeutic targets, and combining the latest multi-omics data and cutting-edge technologies to anticipate the development direction of precise interventions and personalized treatments.