Neutrophil extracellular traps biomarkers are associated with lung function obstruction severity in bronchial asthma.

ObjectiveTo explore the value of neutrophil extracellular traps biomarkers (myeloperoxidase and citrullinated histone H3) in patients with bronchial asthma.MethodsA total of 66 patients with bronchial asthma (stratified into mild, moderate, and severe lung function obstruction subgroups according to predicted forced expiratory volume in 1 second) and 60 healthy controls were enrolled. Plasma levels of myeloperoxidase and citrullinated histone H3 were measured. Spearman correlation analysis and receiver operating characteristic curve analysis were used to evaluate correlations and diagnostic performance.ResultsCompared with healthy controls, patients with bronchial asthma had significantly higher plasma levels of myeloperoxidase and citrullinated histone H3 (all p < 0.001). Myeloperoxidase and citrullinated histone H3 levels increased with the severity of lung function obstruction (severe > moderate > mild; all p < 0.05). Receiver operating characteristic analysis showed that the area under the curve for myeloperoxidase and citrullinated histone H3 alone in diagnosing bronchial asthma was 0.824 and 0.867, respectively.ConclusionPlasma myeloperoxidase and citrullinated histone H3 are elevated in patients with bronchila asthma and are closely associated with the severity of lung function obstruction.