Thermosensitive transient receptor potential channel proteins: Emerging targets for acute lung injury: A review.

The thermosensitive transient receptor potential (Thermo-TRP) channel proteins comprise TRPA1, TRPV1-V4, and TRPM8. TRP channels are mainly situated on cellular surfaces and react to a range of external factors, including heat, cold, acidity, osmotic pressure, chemical signals, and flavors, as well as intracellular signals such as Ca2+, Na+, and cytokines. The thermo-TRP channels are associated with many physiological signal pathways, with their distinct molecular structure making them promising drug targets for respiratory diseases. Acute lung injury (ALI) is a severe, life-threatening syndrome characterized by an intense inflammatory response in the lungs and limited therapeutic options. Thermo-TRP channels play a pivotal role in ALI of various etiologies due to their widespread expression in the lungs, their involvement in modulating inflammatory and structural changes, and their contribution to respiratory symptoms. This review summarizes thermo-TRP channels involvement in the pathogenesis of ALI, particularly that caused by pathogenic microorganisms.