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Войти в исследования Hypertension (Dallas, Tex. : 1979) · 2026
Renal Denervation Improves Hepatic Steatosis in Hypertensive Patients With Metabolic Syndrome.
СтатьяНазвание и аннотация: Перевод в очереди
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Tokcan Mert, Hohl Mathias, Schneider Carolin Victoria, Schneider Kai Markus, Markwirth Philipp, Bernhard Benedikt, Haring Bernhard, Lauder Lucas, Schattenberg Jörn, Mahfoud Felix, Kulenthiran Saarraaken, Böhm Michael
Аннотация
BACKGROUND: Sympathetic overactivity is associated with hepatic steatosis. Renal denervation (RDN) is an approved treatment for uncontrolled hypertension through sympathetic modulation; however, its hepatic effects are unknown. This study aimed to assess the effects of RDN on noninvasive tests for hepatic steatosis.
METHODS: This single-center study included patients with uncontrolled hypertension and cardiometabolic comorbidities undergoing RDN (n=32) or a sham procedure (n=10). Noninvasive tests for hepatic steatosis, including the hepatic steatosis index (HSI) and fatty liver index (FLI), were calculated at baseline and follow-up visits. An external cohort from the UK Biobank was used to validate the correlation between proton density fat fraction magnetic resonance imaging scans of the liver and these surrogates.
RESULTS: Compared with the control group, RDN significantly reduced HSI at 3 months (0.4±0.5 versus -1.3±0.3; P=0.009), 6 months (0.0±0.9 versus -2.6±0.5; P=0.027), and 12 months (0.0±0.6 versus -2.1±0.5; P=0.013), as well as FLI at 3 months (2.6±2.2 versus -3.8±1.2; P=0.021), 6 months (4.1±2.4 versus -5.7±1.2; P=0.002), and 12 months (2.0±2.7 versus -6.2±1.3; P=0.018). No significant differences were found in HSI (-1.9±0.7 versus -2.2±0.7; P=0.77) and FLI (-7.1±1.8 versus -5.3±1.7; P=0.49) between subjects in the intervention group whose office blood pressure decreased above or below the median of 19.5 mm Hg after 12 months. In the UK Biobank, correlation analysis showed a significant relationship between proton density fat fraction magnetic resonance imaging and HSI (r=0.40; P<0.0001) and FLI (r=0.27; P<0.0001).
CONCLUSIONS: RDN significantly reduced HSI and FLI in patients with uncontrolled hypertension and cardiometabolic comorbidities, suggesting a potential role of sympathetic modulation in metabolic disorders.
METHODS: This single-center study included patients with uncontrolled hypertension and cardiometabolic comorbidities undergoing RDN (n=32) or a sham procedure (n=10). Noninvasive tests for hepatic steatosis, including the hepatic steatosis index (HSI) and fatty liver index (FLI), were calculated at baseline and follow-up visits. An external cohort from the UK Biobank was used to validate the correlation between proton density fat fraction magnetic resonance imaging scans of the liver and these surrogates.
RESULTS: Compared with the control group, RDN significantly reduced HSI at 3 months (0.4±0.5 versus -1.3±0.3; P=0.009), 6 months (0.0±0.9 versus -2.6±0.5; P=0.027), and 12 months (0.0±0.6 versus -2.1±0.5; P=0.013), as well as FLI at 3 months (2.6±2.2 versus -3.8±1.2; P=0.021), 6 months (4.1±2.4 versus -5.7±1.2; P=0.002), and 12 months (2.0±2.7 versus -6.2±1.3; P=0.018). No significant differences were found in HSI (-1.9±0.7 versus -2.2±0.7; P=0.77) and FLI (-7.1±1.8 versus -5.3±1.7; P=0.49) between subjects in the intervention group whose office blood pressure decreased above or below the median of 19.5 mm Hg after 12 months. In the UK Biobank, correlation analysis showed a significant relationship between proton density fat fraction magnetic resonance imaging and HSI (r=0.40; P<0.0001) and FLI (r=0.27; P<0.0001).
CONCLUSIONS: RDN significantly reduced HSI and FLI in patients with uncontrolled hypertension and cardiometabolic comorbidities, suggesting a potential role of sympathetic modulation in metabolic disorders.