Alterations in brain physiological pulsations in Parkinson's disease: a case-control study.

INTRODUCTION

Brain physiological pulsations drive glymphatic clearance of neurotoxins from the brain. Neurodegenerative proteinopathies, including Parkinson's disease (PD), have altered glymphatic function. This study compares brain physiological pulsations important for glymphatic clearance in PD and healthy controls (HC).

METHODS

PD (N = 13) and HC (N = 20) participants were evaluated using magnetic resonance encephalography (MREG), an ultrafast, 3D spherical stack-of-spirals dynamic neuroimaging technique, to assess spectral power and optical flow in cardiovascular, respiratory, and low-frequency vasomotor bands as indirect proxies for glymphatic clearance. Group differences were analyzed with two-sample t-tests, controlling for age and sex.

RESULTS

PD participants demonstrated significantly reduced power in the cardiovascular frequency band and reduced optical flow magnitude in the low-frequency vasomotor band in regions important for visual and cognitive processing and sensorimotor function.

CONCLUSION

PD is associated with alterations in physiological pulsations important for glymphatic flow. Glymphatic clearance may represent a potential therapeutic target for neurodegenerative diseases.