Epidemiology of Sudan ebolavirus disease cases in Uganda, January-April, 2025.
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Mfitundinda Emmanuel, Wenani Daniel, Katumba Hannington, Abbo Gertrude, Kobusinge Janet Lubega, Mutesi Charity, Kwizera Patrick, Okello Emmanuel Okiror, Namusisi Annet Mary, Nalwanga Joanita, Ainembabazi Bridget, Namakula Olive Loryndah, Kobusingye Joyce Owens, Kigongo Vianney John, Aujo Deborah, Aman Denise Kyomugisha, Nalweyiso Martha Dorcas, Achom Pauline, Matovu Nasif, Mutegeki Michael, Nakaweesi Winfred, Namasambi Sharon, Nakabuye Maria, Wobusobozi Justine, Namwabira Amina, Alupo Anne Loy, Nabatta Esther, Agwang Winnie, Lugwana Samuel, Rutogire Tracy, Namusoosa Ritah, Opeli Wilfred, Masaba Robert Namisi, Nakaye Martha, Nambaziira Florence, Musubika Caroline, Nakaweesa Vivian, Gidudu Samuel, Akunzirwe Rebecca, Zalwango Jane Frances, Ninsiima Mackline, Eurien Daniel, Byaruhanga Aggrey, Haggai Sunday Kithula, Lubwama Bernard, Bwire Godfrey, Ebong Moses, Atim Dansan, Eyu Patricia, Nansikombi Hildah Tendo, Kyamwine Irene Byakatonda, Morukileng Job, Migisha Richard, Kwesiga Benon, Okello Paul Edward, Bulage Lilian, Smith Kami L, Ojwang Joseph, Wasike Sam, Balinandi Stephen, Nyakarahuka Luke, Lutwama Julius Julian, Kaleebu Pontiano, Nabatanzi Sandra, Gianetti Brittany, Kadobera Daniel, Muruta Allan N, Boyd Mary A, Ario Alex Riolexus
Аннотация
METHODS: SVD cases were identified using MoH case definitions and were classified as confirmed if positive on RT-qPCR or probable if an SVD-related death was reported with epidemiological linkage but without laboratory confirmation. Cases were identified through contact tracing, community and health facility alerts, and active search. Data were collected using a standard SVD case investigation form, including demographics, exposures and outcome. The effective reproductive number (Rt) was estimated using the EpiEstim package in R.
RESULTS: Fourteen cases were identified between January 30 and April 25, 2025: 12 (86%) were confirmed and two (14%) were probable; and five (36%) were health workers. The mean (range) age was 27 (0-50) years. Four cases died, a case fatality rate (CFR) of 29% (4/14). Most exposures were household (9[64%]) followed by healthcare-associated exposures (3[21%]). The index case was a health worker who died of a febrile illness 11 days after symptom onset, and postmortem samples returned positive for SUDV on the same day. A total of 534 contacts were monitored; of these, 454 (85%) were quarantined. Ten cases were known contacts; no secondary transmission occurred among these cases. The estimated Rt (interquartile range) was 1.1 (0.83-1.35).
CONCLUSION: The outbreak had a low CFR and a low Rt, possibly due to early detection and swift identification, quarantine, and close monitoring of contacts.