Journal of assisted reproduction and genetics · 2009
A case of an infertile male with a small supernumerary marker chromosome negative for M-FISH and containing only heterochromatin.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Wang Wei, Hu Yali, Zhu Haiyan, Li Jie, Zhu Ruifang, Wang Ya-Ping
Аннотация
AIM: To describe the case of a 32-year-old infertile male with small supernumerary marker chromosome (sSMCs) in 80% of peripheral lymphocytes.
METHODS: G-banding, C-banding, STRP analysis, M-FISH and molecule diagnosis of Y-chromosomal microdeletions were performed to determine the origin of sSMCs.
RESULTS: The karyotype of this patient was established as 47, XY, +mar/46, XY. C-banding showed that the marker chromosome was composed of heterochromatin without visible euchromatic material. No positive result was obtained in STRP, M-FISH and the microdeletion analysis of Y- chromosome.
CONCLUSIONS: The small supernumerary marker chromosome could play a causative role in male infertility although the mechanism remains to be elucidated.
METHODS: G-banding, C-banding, STRP analysis, M-FISH and molecule diagnosis of Y-chromosomal microdeletions were performed to determine the origin of sSMCs.
RESULTS: The karyotype of this patient was established as 47, XY, +mar/46, XY. C-banding showed that the marker chromosome was composed of heterochromatin without visible euchromatic material. No positive result was obtained in STRP, M-FISH and the microdeletion analysis of Y- chromosome.
CONCLUSIONS: The small supernumerary marker chromosome could play a causative role in male infertility although the mechanism remains to be elucidated.