{Zn6Na} heptanuclear cluster based heterometallic framework as an intelligent luminescent sensor for efficient detection of carcinoid biomarkers.

Precise and rapid detection of carcinoid biomarkers in bodily fluids is critical for disease diagnosis and treatment. In this work, a 3D porous framework, {[Zn3Na0.5(DPIA)(μ3-OH)0.5(μ2-OH2)(H2O)1.5]·5H2O}n (ZnNaMOF), was successfully synthesized using 4,6-bis(2,4-dicarboxyphenyl)isophthalic acid (H6DPIA). ZnNaMOF displays an unprecedented {Zn6Na(COO)12} heptanuclear cluster based 3D porous architecture with 45% porosity, and shows exceptional chemical stability. Exploiting PET induced luminescence enhancement, ZnNaMOF demonstrates high potential as a luminescent sensor for quantitative detection of 5-HIAA and 5-HT biomarker, exhibiting high selectivity, sensitivity, strong anti-interference capability, and low detection limits (8.34 nM for 5-HIAA, 6.21 nM for 5-HT). Furthermore, Boolean logic gate-based intelligent detection platforms were developed to enhance the convenience and practicality of urinary 5-HIAA and serum 5-HT level monitoring.