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Войти в исследования Respiration; international review of thoracic diseases · 2026
Effect of Azithromycin in Addition to Inhaled Corticosteroids in Severe Preschool Wheeze: A Retrospective Cohort Study.
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Dumenil Meryl, Grosjean Julien, Couderc Laure, Lubrano-Lavadera Marc, Medghoul Lamia, Michelet Isabelle, Raghani Juliette, Marguet Christophe, Petat Hortense
Аннотация
INTRODUCTION: Preschool wheeze is common, and treatment options are limited, consisting mainly of inhaled corticosteroids (ICS). We report here a retrospective study in severe preschool wheezers not controlled by high doses of ICS, who were given azithromycin as long-term additional therapy.
METHODS: We conducted a single-center, retrospective study between 2020 and 2025, including children less than 6 years old with severe recurrent wheeze, partially or uncontrolled despite a high dose of ICS and who were given azithromycin three times a week for 6 months as maintenance treatment.
RESULTS: Thirty-eight children with a mean age of 2.3 ± 1.2 years were retrospectively included in our center. We found an improvement in the control of wheezing and a decrease of exacerbations, daily respiratory symptoms, and dose of daily ICS after 6 months of azithromycin treatment, without major secondary effect declared.
CONCLUSION: Azithromycin could therefore be considered as an adjunctive treatment in young children with persistent asthma and frequent exacerbations despite high doses of inhaled steroids. This conclusion is from a retrospective study, and it is needed to perform controlled prospective studies to validate these findings.
METHODS: We conducted a single-center, retrospective study between 2020 and 2025, including children less than 6 years old with severe recurrent wheeze, partially or uncontrolled despite a high dose of ICS and who were given azithromycin three times a week for 6 months as maintenance treatment.
RESULTS: Thirty-eight children with a mean age of 2.3 ± 1.2 years were retrospectively included in our center. We found an improvement in the control of wheezing and a decrease of exacerbations, daily respiratory symptoms, and dose of daily ICS after 6 months of azithromycin treatment, without major secondary effect declared.
CONCLUSION: Azithromycin could therefore be considered as an adjunctive treatment in young children with persistent asthma and frequent exacerbations despite high doses of inhaled steroids. This conclusion is from a retrospective study, and it is needed to perform controlled prospective studies to validate these findings.