Oral surgery, oral medicine, oral pathology and oral radiology · 2013
Commercial mouthwashes are ineffective against oral MRSA biofilms.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Smith Karen, Robertson Douglas P, Lappin David F, Ramage Gordon
Аннотация
OBJECTIVE: The aim of this study was to evaluate and compare the activity of oral mouthwashes against biofilm forms of MRSA isolated from the oral cavity and the bloodstream.
STUDY DESIGN: The time-kill kinetics efficacy of 7 over-the-counter mouthwashes were tested against 28 clinical MRSA biofilm isolates for 0.5, 1 and 2 min.
RESULTS: Treatments of MRSA biofilms formed by oral and bloodstream isolates were not significantly different, with mouthwashes displaying a rapid and modest anti-biofilm effect. None of the biofilm isolates were completely eradicated by the compounds tested, with a maximal killing of only approximately 70% shown by Corsodyl and Peroxyl. Maximum activity of all compounds tested was observed after 0.5 min. Fluorigard showed the poorest overall activity (57% reduction).
CONCLUSIONS: MRSA colonize the oral cavity, and are more prevalent in institutionalized persons and the elderly. Over-the-counter mouthwashes are ineffective at killing MRSA biofilms, which has infection control implications.
STUDY DESIGN: The time-kill kinetics efficacy of 7 over-the-counter mouthwashes were tested against 28 clinical MRSA biofilm isolates for 0.5, 1 and 2 min.
RESULTS: Treatments of MRSA biofilms formed by oral and bloodstream isolates were not significantly different, with mouthwashes displaying a rapid and modest anti-biofilm effect. None of the biofilm isolates were completely eradicated by the compounds tested, with a maximal killing of only approximately 70% shown by Corsodyl and Peroxyl. Maximum activity of all compounds tested was observed after 0.5 min. Fluorigard showed the poorest overall activity (57% reduction).
CONCLUSIONS: MRSA colonize the oral cavity, and are more prevalent in institutionalized persons and the elderly. Over-the-counter mouthwashes are ineffective at killing MRSA biofilms, which has infection control implications.
Предметные рубрики MeSH
AloeAnti-Infective Agents, LocalBacteremiaBacteriological TechniquesBenzoatesBiofilmsCetylpyridiniumChlorhexidineDrug CombinationsDrug Resistance, BacterialHumansHydrogen PeroxideIndicators and ReagentsMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMouthMouthwashesPlant PreparationsSalicylatesSodium Dodecyl SulfateTea Tree OilTerpenesTetrazolium SaltsTime FactorsTriclosan