Danish medical journal · 2023
Olfactory training in long COVID-19 patients with lasting symptoms including olfactory dysfunction.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Fjaeldstad Alexander W, Ovesen Thomas, Stankevice Dovile, Ovesen Therese
Аннотация
INTRODUCTION: Two-thirds of patients with COVID-19 developed smell and taste dysfunction, of whom half experienced improvement within the first month. After six months, 5-15% still suffered from significant olfactory dysfunction (OD). Before COVID-19, olfactory training (OT) was proved to be effective in patients with post-infectious OD. Therefore, the present study aimed to investigate the progress of olfactory recovery with and without OT in patients with long COVID-19.
METHODS: Consecutive patients with long COVID-19 referred to the Flavour Clinic at Gødstrup Regional Hospital, Denmark, were enrolled. The diagnostic set-up at the first visit and follow-up included smell and taste tests, questionnaires, ENT examination and instructions in OT.
RESULTS: From January 2021 to April 2022, 52 patients were included due to long COVID-19-related OD. The majority of patients complained of distorted sensory quality, in particular, parosmia. Two-thirds of the patients reported a subjective improvement of their sense of smell and taste along with a significant decline in the negative impact on quality of life (p = 0.0001). Retesting at follow-up demonstrated a significant increase in smell scores (p = 0.023) where a minimal clinically important difference (MCID) in smell scores was found in 23% of patients. Full training compliance was significantly associated with the probability of MCID improvement (OR = 8.13; p = 0.04).
CONCLUSIONS: The average effect of OT is modest; however, full training compliance was significantly associated with an increased probability of a clinically relevant olfactory improvement.
FUNDING: none.
TRIAL REGISTRATION: not relevant.
METHODS: Consecutive patients with long COVID-19 referred to the Flavour Clinic at Gødstrup Regional Hospital, Denmark, were enrolled. The diagnostic set-up at the first visit and follow-up included smell and taste tests, questionnaires, ENT examination and instructions in OT.
RESULTS: From January 2021 to April 2022, 52 patients were included due to long COVID-19-related OD. The majority of patients complained of distorted sensory quality, in particular, parosmia. Two-thirds of the patients reported a subjective improvement of their sense of smell and taste along with a significant decline in the negative impact on quality of life (p = 0.0001). Retesting at follow-up demonstrated a significant increase in smell scores (p = 0.023) where a minimal clinically important difference (MCID) in smell scores was found in 23% of patients. Full training compliance was significantly associated with the probability of MCID improvement (OR = 8.13; p = 0.04).
CONCLUSIONS: The average effect of OT is modest; however, full training compliance was significantly associated with an increased probability of a clinically relevant olfactory improvement.
FUNDING: none.
TRIAL REGISTRATION: not relevant.