Journal of gynecology obstetrics and human reproduction · 2026
Prenatal alcohol exposure and sonographic abnormalities: Insights from a retrospective cohort.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Sizaire Margaux, Galvan Lucie, Peyronnet Violaine, Holmström Emilia, Egloff Charles, Pauphilet Victoire, Picone Oliver, Mandelbrot Laurent, Ben M'Barek Imane
Аннотация
CONTEXT: Foetal Alcohol Syndrome (FAS) is the most severe form of Foetal Alcohol Spectrum Disorders (FASD), caused by prenatal alcohol exposure, a major preventable cause of congenital disability. FASD lack specific prenatal ultrasound signs, making early diagnosis difficult.
OBJECTIVE: To describe prenatal ultrasound findings in pregnancies with reported alcohol use and compare maternal and neonatal characteristics according to the presence of anomalies.
METHODS: We conducted a retrospective multicentre study in three hospitals from September 2013 to April 2025. All women reporting alcohol use during pregnancy were included. Exposure was classified by quantity (moderate: ≤3 drinks/day or <40 cl/day; excessive: >3 drinks/day or >40 cl/day) and frequency (occasional, often, chronic), based on maternal self-report. Ultrasound scans from all trimesters were reviewed for growth and morphological anomalies. Comparative analyses were performed between women with and without anomalies.
RESULTS: Among 94 pregnancies, 30 (32%) showed ultrasound anomalies. Women with anomalies were older (33.9 vs. 31.7 years, p <0.01), with no differences in BMI, parity, or co-exposures. Occasional alcohol use appeared not associated with anomalies, whereas increasing maternal age (aOR = 1.22; 95% CI [1.09-1.40]) was an independent risk factor. Most anomalies were detected in the second trimester, mainly foetal growth restriction (FGR) and microcephaly. Neonatal abnormalities occurred in 70% of the anomaly group versus 10.9% without anomalies (p < 0.01). Seven neonates (11%) had undiagnosed FGR or microcephaly at birth.
CONCLUSION: Ultrasound anomalies were found in one-third of alcohol-exposed pregnancies, underscoring the risks of chronic alcohol use.
OBJECTIVE: To describe prenatal ultrasound findings in pregnancies with reported alcohol use and compare maternal and neonatal characteristics according to the presence of anomalies.
METHODS: We conducted a retrospective multicentre study in three hospitals from September 2013 to April 2025. All women reporting alcohol use during pregnancy were included. Exposure was classified by quantity (moderate: ≤3 drinks/day or <40 cl/day; excessive: >3 drinks/day or >40 cl/day) and frequency (occasional, often, chronic), based on maternal self-report. Ultrasound scans from all trimesters were reviewed for growth and morphological anomalies. Comparative analyses were performed between women with and without anomalies.
RESULTS: Among 94 pregnancies, 30 (32%) showed ultrasound anomalies. Women with anomalies were older (33.9 vs. 31.7 years, p <0.01), with no differences in BMI, parity, or co-exposures. Occasional alcohol use appeared not associated with anomalies, whereas increasing maternal age (aOR = 1.22; 95% CI [1.09-1.40]) was an independent risk factor. Most anomalies were detected in the second trimester, mainly foetal growth restriction (FGR) and microcephaly. Neonatal abnormalities occurred in 70% of the anomaly group versus 10.9% without anomalies (p < 0.01). Seven neonates (11%) had undiagnosed FGR or microcephaly at birth.
CONCLUSION: Ultrasound anomalies were found in one-third of alcohol-exposed pregnancies, underscoring the risks of chronic alcohol use.