MedElevator
Войти в исследования Sustained Reduction in Cardiopulmonary Fitness in Long COVID: A Report from the RECOVER-adult Cohort Study.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Vogel Julia Moore, Jenkins Trevor, Cerda Marta, Chen Hillary, Goldman Jason, Katz Stuart D, Patterson Thomas F, Ashktorab Hassan, Bartram Logan, Barua Souptik, Brim Hassan, Brown Jeanette P, Castro Mario, Chaibub Neto Elias, Chestek David, Durstenfeld Matthew S, Erlandson Kristine M, Flaherman Valerie, Foulkes Andrea S, Ghamloush Maher, Haddad Francois, Hadlock Jennifer, Heath James R, Hornikel Bjoern, Karlson Elizabeth W, Kaufman Elizabeth S, Kellogg Dean L, Levitan Emily B, Levy Bruce D, Martin Jeff, McComsey Grace A, Metz Torri D, Motl Robert W, Moukabary Talal, Mullington Janet M, Ofotokun Igho, Okumura Megumi J, Parthasarathy Sairam, Plunkett Beth A, Reeves W Brian, Rischard Franz, Rizzo JohnRoss, Scott Jake A, Sherif Zaki A, Thaweethai Tanayott, Trinity Joel D, Tummalacherla Meghasyam, Urdaneta Alfredo E, Vasey Andrew J, Villanueva Daphne-Dominique, Walker Tiffany A, Wiley Zanthia, Sieberts Solveig K, Krishnan Jerry A, RECOVER Consortium
Аннотация
OBJECTIVES: The objective of the study was to characterize cardiopulmonary function after SARS-CoV-2 infection in a digital health substudy of the nationwide Researching COVID-19 to Enhance Recovery Adult Cohort Study.
METHODS: Associations between wearable sensor device measures of cardiopulmonary fitness and survey-derived Long COVID symptoms were estimated over a 6-month window at least 6 months after infection using linear regression models adjusted for wear time, age, sex, race/ethnicity, and body mass index.
RESULTS: Among 1,475 participants (72% female, 65% non-Hispanic White) a median of 21 months (IQR: 15-31 months) after infection, 498 (34%) had high symptom burden as characterized by the Researching COVID-19 to Enhance Recovery Long COVID Research Index (LCRI). High LCRI (vs low LCRI) was associated with significantly lower heart rate variability (-4.4 ms; 95% CI: -6.5 to -2.4; P < 0.001), higher resting heart rate (+1.5 beats/min [+0.7 to +2.4]; P < 0.001), fewer metabolic equivalent of task minutes (-96.3 [-128.8 to -63.8]; P < 0.001), lower step counts (-1,624 steps/day [-1,952 to -1,296]; P < 0.001), and lower activity levels (-7.9 minutes/day very or fairly active [-10.9 to -5.0]; P < 0.001). Hierarchal clustering analysis identified two subphenotypes with abnormal cardiovascular measures associated with low quality of life scores.
CONCLUSIONS: Long COVID is associated with worse cardiovascular fitness. Additional studies are needed to determine if Long COVID is a novel risk factor for incident cardiovascular disease.