Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics · 2009
[The investigation of the relationship between the phenotypes of 46, XX males and the SRY gene].
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Wang Yue-ping, Zhao Yun-jing, Ruan Qiang, Ji Yao-hua, Hao Ming-ge, Jiang Wei-hua
Аннотация
OBJECTIVE: To investigate the relationship between the phenotypes in XX male patients and the sex determining region(SRY) gene.
METHODS: Multiple polymerase chain reactions were carried out in 6 male patients with karyotype of 46, XX, and then the PCR products were sequenced directly.
RESULTS: Three cases of male infertility were positive for the SRY gene without evident malformation in their extra genitalia, while 3 cases with testes were negative for the SRY gene, with evident malformation in their extra genitalia.
CONCLUSION: The SRY gene is key in sex determination and development, yet there might be other important genes involved.
METHODS: Multiple polymerase chain reactions were carried out in 6 male patients with karyotype of 46, XX, and then the PCR products were sequenced directly.
RESULTS: Three cases of male infertility were positive for the SRY gene without evident malformation in their extra genitalia, while 3 cases with testes were negative for the SRY gene, with evident malformation in their extra genitalia.
CONCLUSION: The SRY gene is key in sex determination and development, yet there might be other important genes involved.