World journal of gastrointestinal surgery · 2025
Effect of comorbid gastroesophageal reflux disease on laryngopharyngeal reflux disease: Clinical characteristics and risk factors.
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Xu Dan-Dan
Аннотация
BACKGROUND: Research thoroughly examining how gastroesophageal reflux disease (GERD) affects clinical presentations in patients with laryngopharyngeal reflux disease (LPRD) and exploring the associated triggers is limited.
AIM: To investigate the effect of comorbid GERD on the clinical characteristics of patients with LPRD and determine risk contributors.
METHODS: In total, 150 patients with LPRD admitted between October 2022 and October 2024 were divided into the GERD (n = 74) or non-GERD (n = 76) group based on their comorbid GERD status. The clinical data collected included age, sex, body mass index (BMI), marital status, smoking, alcohol consumption, and eating habits in the 3-hour window before sleep. The following reflux-related symptoms were recorded: (1) Hoarseness/voice disorders; (2) Persistent throat clearing; (3) Excessive phlegm/postnasal drip; (4) Difficulty swallowing food or water; (5) Postprandial or supine coughing; (6) Breathing difficulties; (7) Bothersome cough; (8) Throat foreign body sensation; (9) Heartburn, chest pain; and (10) Stomach pain. The Reflux Symptom Index (RSI) and Reflux Finding Score (RFS) tools were used. Binary logistic regression identified contributors to GERD in LPRD.
RESULTS: Compared with the non-GERD group, the GERD group, with a notably higher BMI, included greater proportions of older patients, female patients, smokers, and alcohol users and a higher prevalence of bothersome cough, heartburn, chest pain, and stomach pain; however, excessive phlegm or postnasal drip was less common. Additionally, patients with LPRD and comorbid GERD had notably higher RSI and RFS scores. Age (P = 0.017), sex (P = 0.029), smoking (P = 0.012), and alcohol consumption (P = 0.036) were significant triggers for GERD comorbidity in LPRD.
CONCLUSION: Comorbid GERD exacerbates clinical manifestations of patients with LPRD. Advanced age, female sex, smoking, and alcohol consumption predispose patients with LPRD to GERD development.
AIM: To investigate the effect of comorbid GERD on the clinical characteristics of patients with LPRD and determine risk contributors.
METHODS: In total, 150 patients with LPRD admitted between October 2022 and October 2024 were divided into the GERD (n = 74) or non-GERD (n = 76) group based on their comorbid GERD status. The clinical data collected included age, sex, body mass index (BMI), marital status, smoking, alcohol consumption, and eating habits in the 3-hour window before sleep. The following reflux-related symptoms were recorded: (1) Hoarseness/voice disorders; (2) Persistent throat clearing; (3) Excessive phlegm/postnasal drip; (4) Difficulty swallowing food or water; (5) Postprandial or supine coughing; (6) Breathing difficulties; (7) Bothersome cough; (8) Throat foreign body sensation; (9) Heartburn, chest pain; and (10) Stomach pain. The Reflux Symptom Index (RSI) and Reflux Finding Score (RFS) tools were used. Binary logistic regression identified contributors to GERD in LPRD.
RESULTS: Compared with the non-GERD group, the GERD group, with a notably higher BMI, included greater proportions of older patients, female patients, smokers, and alcohol users and a higher prevalence of bothersome cough, heartburn, chest pain, and stomach pain; however, excessive phlegm or postnasal drip was less common. Additionally, patients with LPRD and comorbid GERD had notably higher RSI and RFS scores. Age (P = 0.017), sex (P = 0.029), smoking (P = 0.012), and alcohol consumption (P = 0.036) were significant triggers for GERD comorbidity in LPRD.
CONCLUSION: Comorbid GERD exacerbates clinical manifestations of patients with LPRD. Advanced age, female sex, smoking, and alcohol consumption predispose patients with LPRD to GERD development.