Single Nucleotide Variants of the SLC2A9 Gene Are Associated with Hyperuricemia in Mexican Patients with Type 2 Diabetes.

BACKGROUND

Chronic kidney disease (CKD) due to diabetes is the third leading cause of death in Mexico. A relationship between high serum uric acid (SUA) levels and kidney disease have been demonstrated. On the other hand, variants of the SLC2A9 gene have been associated with elevated SUA concentrations. This study evaluated the associations of the rs11722228, rs3775948, rs7678287, and rs1014290 variants with hyperuricemia and biochemical parameters in patients with type 2 diabetes (T2D).

METHODS

The study included 1036 Mexican subjects with T2D. Patients were grouped based on the presence (n = 462) or absence (n = 574) of diabetic kidney disease (DKD). SUA concentrations and biochemical parameters were determined. Samples were genotyped through real-time polymerase chain reaction. Associations between genetic variants and hyperuricemia were analyzed by univariate and multivariate models adjusting for covariates.

RESULTS

SUA levels and hyperuricemia prevalence were higher in the DKD group. rs3775948 and rs1014290 showed negative associations with hyperuricemia in the whole sample and in patients without DKD. rs7678287 was positively correlated with SUA and hyperuricemia in patients without DKD, whereas rs11722228 was a risk factor only in the DKD group. The presence of DKD and elevated triglycerides and total cholesterol were significant factors associated with hyperuricemia.

CONCLUSIONS

Variants rs3775948 and rs1014290 exhibit protective effects, while rs7678287 and rs11722228 may confer increased risk of hyperuricemia in Mexican patients with T2D. Analysis of SLC2A9 gene variants could help in detecting patients at increased risk of kidney or cardiovascular complications due to hyperuricemia.