Veterinary medicine international · 2025
Anesthetic Protocols for Enhancing Physiological Stability in Rabbits During Hemorrhagic Shock.
СтатьяНазвание и аннотация: Перевод в очереди
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Dandea Ştefania-Mădălina, Peștean Cosmin-Petru, Melega Iulia, Codea Razvan-Andrei, Bel Lucia-Victoria, Hașaș Alina-Diana, Popovici Cristian-Paul, Sevastre Bogdan
Аннотация
STUDY BACKGROUND: Rabbits are commonly used in experimental research; however, their sensitivity to handling-induced stress and cardiovascular instability poses considerable challenges. These complications are not fully prevented by standard preanesthetic medication, making them less reliable, particularly in studies involving hemorrhagic shock.
AIM: The aim of this study was to identify enhanced anesthetic protocols that effectively maintain physiological stability and prevent respiratory or cardiac failure during the induction of hemorrhagic shock.
METHODS: Fifteen adult female New Zealand White rabbits were divided into three equal groups: one received dexmedetomidine and ketamine; the other received the same induction followed by isoflurane maintenance; while the third, in addition to the medication of the second group, received a constant rate ketamine infusion. Vital parameters such as heart rate, blood pressure, oxygen saturation, end-tidal CO2, reflexes, and core body temperature were continuously monitored. Hemorrhagic shock was induced by withdrawing 40% of the total blood volume through a surgically cannulated carotid artery.
RESULTS: Among the three, the third protocol provided the most consistent anesthesia depth in conjunction with stable vital signs, ensuring animal safety and effective modeling of hemorrhagic shock.
CONCLUSIONS: These results support the use of a combined inhalant anesthetic with continuous ketamine infusion to enhance physiological stability in rabbits during complex procedures, ultimately improving both the reliability of experimental data and animal welfare.
AIM: The aim of this study was to identify enhanced anesthetic protocols that effectively maintain physiological stability and prevent respiratory or cardiac failure during the induction of hemorrhagic shock.
METHODS: Fifteen adult female New Zealand White rabbits were divided into three equal groups: one received dexmedetomidine and ketamine; the other received the same induction followed by isoflurane maintenance; while the third, in addition to the medication of the second group, received a constant rate ketamine infusion. Vital parameters such as heart rate, blood pressure, oxygen saturation, end-tidal CO2, reflexes, and core body temperature were continuously monitored. Hemorrhagic shock was induced by withdrawing 40% of the total blood volume through a surgically cannulated carotid artery.
RESULTS: Among the three, the third protocol provided the most consistent anesthesia depth in conjunction with stable vital signs, ensuring animal safety and effective modeling of hemorrhagic shock.
CONCLUSIONS: These results support the use of a combined inhalant anesthetic with continuous ketamine infusion to enhance physiological stability in rabbits during complex procedures, ultimately improving both the reliability of experimental data and animal welfare.