Taurine attenuates high-fat high-sugar diet-induced endoplasmic reticulum stress-mediated hepatocyte apoptosis.

High-fat and high-sugar diets lead to fat deposition and metabolic disorders in mammalian livers, causing chronic liver disease. The effect of high fat and high sugar on hepatocyte function is closely related to endoplasmic reticulum stress. Taurine regulates lipid metabolism, reduces fat deposition and inhibits apoptosis. In this study, the relationship between taurine deficiency and taurine supplementation was investigated through both perspectives. The results showed that taurine synthesis rate-limiting enzyme deficiency could cause abnormal hepatic lipid metabolism, endoplasmic reticulum stress and hepatocyte injury. Taurine supplementation reduced blood glucose, hepatic endoplasmic reticulum stress and hepatocyte apoptosis. In short, taurine reduced hepatocyte apoptosis by attenuating hepatic endoplasmic reticulum stress.