European journal of radiology · 2025
Association between deep learning radiomics based on placental MRI and preeclampsia with fetal growth restriction: A multicenter study.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Zheng Weizeng, Jiang Ying, Jiang Zekun, Li Juan, Bian Wei, Hou Hongtao, Yan Guohui, Shen Wei, Zou Yu, Luo Qiong
Аннотация
PURPOSE: Preeclampsia (PE) is associated with placental insufficiency and could lead to adverse pregnancy outcomes. The study aimed to develop a placental T2-weighted image-based automatic quantitative model for the identification of PE pregnancies and disease severity.
METHODS: Between July 2013 and September 2022, the retrospective multicenter study featured 420 pregnant women, including 140 cases of PE and 280 cases of normotensive pregnancies. The semi-supervised approach was used to gain an automatic segmentation for placental MRI. The radiomics, deep learning, and deep learning radiomics (DLR) models were built.
RESULTS: In PE pregnancies, 65 (46.4 %) fetuses developed PE with fetal growth restriction (FGR), and 75 (53.6 %) cases were PE without FGR. The Dice of semi-supervised placental segmentation was 0.917. The AUCs of the DLR signature for discriminating PE pregnancies from normotensive pregnancies were 0.839 (95 % CI: 0.793-0.886), 0.858 (95 % CI: 0.742-0.974), 0.888 (95 % CI: 0.783-0.992), and 0.843 (95 % CI: 0.731-1.000) in the training, test, internal validation, and external validation sets, respectively. This DLR analysis model performed well in discriminating between PE with FGR and normotensive pregnancies (AUC = 0.918, 95 % CI: 0.879-0.957) and PE without FGR (AUC = 0.742, 95 % CI: 0659-0.824).
CONCLUSION: The automatic radiomics analysis has been developed to identify PE pregnancies by determining DLR features on placental T2-weighted images, and to predict FGR exposed to PE.
METHODS: Between July 2013 and September 2022, the retrospective multicenter study featured 420 pregnant women, including 140 cases of PE and 280 cases of normotensive pregnancies. The semi-supervised approach was used to gain an automatic segmentation for placental MRI. The radiomics, deep learning, and deep learning radiomics (DLR) models were built.
RESULTS: In PE pregnancies, 65 (46.4 %) fetuses developed PE with fetal growth restriction (FGR), and 75 (53.6 %) cases were PE without FGR. The Dice of semi-supervised placental segmentation was 0.917. The AUCs of the DLR signature for discriminating PE pregnancies from normotensive pregnancies were 0.839 (95 % CI: 0.793-0.886), 0.858 (95 % CI: 0.742-0.974), 0.888 (95 % CI: 0.783-0.992), and 0.843 (95 % CI: 0.731-1.000) in the training, test, internal validation, and external validation sets, respectively. This DLR analysis model performed well in discriminating between PE with FGR and normotensive pregnancies (AUC = 0.918, 95 % CI: 0.879-0.957) and PE without FGR (AUC = 0.742, 95 % CI: 0659-0.824).
CONCLUSION: The automatic radiomics analysis has been developed to identify PE pregnancies by determining DLR features on placental T2-weighted images, and to predict FGR exposed to PE.