Adiponectin and resistin in relationship with skeletal status in women from the RAC-OST-POL study.

INTRODUCTION

The aim of this study was to establish adiponectin and resistin serum levels and their relationship with skeletal status in women from the RAC-OST-POL study.

MATERIAL AND

METHODS

40 women with the lowest and 40 women with the highest value of bone mineral density (BMD) measured at the femoral neck (FN) were selected from a total of 625 women after dividing them into six age categories. Mean age in the whole group of 80 women was 66.1 ± 8.0 years. 22 women had osteoporotic fractures. Adiponectin and resistin were measured, and skeletal assessment included measurements of BMD of FN and total hip (TH) using Lunar DPX (USA) and quantitative ultrasound (QUS) of hand phalanges by means of DBM Sonic 1200 (IGEA, Italy).

RESULTS

Mean age did not differ between the subgroups, whereas height, weight, BMI and BMD were significantly higher in women with high BMD values. In women with high and low BMD, adiponectin concentration [μg/mL] was 24.81 ± 12.7 and 31.04 ± 12.64 respectively, and differed significantly (p 〈 0.05). Respective values for resistin concentration [ng/mL] were 3.29 ± 1.37 and 3.62 ± 1.45, and did not differ. Adiponectin negatively correlated with weight (r = -0.34, p 〈 0.01), BMI (r = -0.37, p 〈 0.01), FN BMD (r = -0.26, p 〈 0.05), TH BMD (r = -0.33, p 〈 0.01), and did not correlate with QUS result. Stepwise multiple regression analysis showed that TH BMD was negatively influenced by age and adiponectin and positively by weight, and that FN BMD was dependent on age and weight only.

CONCLUSIONS

Our results suggest that adiponectin may be an independent factor influencing skeletal status in women aged over 55 years.