Adjustable crystallinity of covalent organic frameworks for electrochemical aptasensing of penicillin.

Covalent organic frameworks (COFs) show a great potential application in the field of constructing electrochemical aptasensors due to their high specific surface area, abundant pores, and good stability. Crystallinity (i.e., orderliness) is directly related to the structural characteristics of porous frameworks and affects their sensing performance. However, few reports focus on the influence of crystallinity on electrocatalytic aptasensing performance. This work develops copper porphyrin-based COFs with different crystallinity to fabricate electrochemical aptasensors for detecting penicillin. The research results indicate that highly ordered COF has higher specific surface area and ordered pores, which can significantly improve sensing performance.