Uric Acid-to-Albumin Ratio Is Associated with Left Ventricular Diastolic Function in Patients with No Significant Perfusion Abnormality.

The ratio of uric acid to albumin is a marker of not only inflammation, but also prognosis of cardiovascular disease. However, whether this ratio is associated with left ventricular (LV) diastolic function remains unknown. This study tested the hypothesis that the uric acid-to-albumin ratio (UAR) is associated with LV diastolic parameters derived from gated myocardial perfusion single-photon emission computed tomography (SPECT) in patients with no significant perfusion abnormalities.Participants in this retrospective study comprised 216 patients with no significant perfusion abnormalities and preserved ejection fraction. The peak filling rate (PFR) and one-third mean filling rate (1/3 MFR) were obtained as LV diastolic parameters using gated SPECT. Serum levels of uric acid and albumin were also examined.Significant associations were observed between the UAR and both the PFR (r = -0.22, P = 0.001) and 1/3 MFR (r = -0.23, P = 0.001). Multivariate linear regression analysis was performed to determine factors associated with LV diastolic parameters. Age (β = -0.14, P = 0.045), LV end-diastolic volume (β = -0.26, P = 0.001), and the UAR (β = -0.16, P = 0.024) were significantly associated with the PFR. Moreover, age (β = -0.19, P = 0.004), LV mass index (β = -0.21, P = 0.001), and the UAR (β = -0.14, P = 0.047) were significantly associated with the 1/3 MFR.These results demonstrate that the UAR is associated with LV diastolic function, as derived from gated SPECT in patients with no significant perfusion abnormalities.