Fertility and sterility · 2001
Herniated blastomere following chemically assisted hatching may result in monozygotic twins.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Sheen T C, Chen S R, Au H K, Chien Y Y, Wu K Y, Tzeng C R
Аннотация
OBJECTIVE: To explore a possible mechanism of the increasing incidence of monozygotic twins following assisted hatching of human embryos.
DESIGN: Case report.
SETTING: Clinical research center in a medical school teaching hospital.
PATIENT: A 37-year-old infertile woman with repeated IVF failures.
INTERVENTION(S): Assisted hatching of the day 3 embryos using acidic Tyrode's solution.
MAIN OUTCOME MEASURE(S): The morphology of the zona-drilled embryos and the pregnancy outcome.
RESULT(S): After assisted hatching, a herniated blastomere through an oversized opening in the zona pellucida was found in one embryo. The transfer of two zona-drilled embryos resulted in a triplet pregnancy.
CONCLUSION(S): Large openings in the zona pellucida following chemically assisted hatching may cause premature hatching of the blastomeres and may be implicated in the occurrence of monozygotic twins.
DESIGN: Case report.
SETTING: Clinical research center in a medical school teaching hospital.
PATIENT: A 37-year-old infertile woman with repeated IVF failures.
INTERVENTION(S): Assisted hatching of the day 3 embryos using acidic Tyrode's solution.
MAIN OUTCOME MEASURE(S): The morphology of the zona-drilled embryos and the pregnancy outcome.
RESULT(S): After assisted hatching, a herniated blastomere through an oversized opening in the zona pellucida was found in one embryo. The transfer of two zona-drilled embryos resulted in a triplet pregnancy.
CONCLUSION(S): Large openings in the zona pellucida following chemically assisted hatching may cause premature hatching of the blastomeres and may be implicated in the occurrence of monozygotic twins.