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Войти в исследования Respiratory medicine case reports · 2018
Paraneoplastic limbic encephalitis revealing a small cell carcinoma of the lung.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Kacem Marwa, Belloumi Nidhal, Bachouche Imene, Mersni Mariem, Chermiti Ben Abdallah Fatma, Fenniche Soraya
Аннотация
INTRODUCTION: Paraneoplastic limbic encephalitis is a rare disease, usually associated with small cell lung cancer.
CASE REPORT: We report in this publication the cases with different age brackets, who presented with various neurological symptoms such as repetitive seizures or anterograde amnesia. Cerebral CT-scan, cerebral MRI and anti onco-neural paraneoplastic antibodies were suggesting the diagnosis of paraneoplastic limbic encephalitis. Etiological exploration lead to the diagnosis of locally advanced small cell carcinoma of the lung. We started rapidly a curative protocol associating chemotherapy and sequential thoracic radiotherapy.
CONCLUSIONS: we insist on the diversity of the imaging findings, immunological analyses and outcome on treatment of this entity. Prognostic impact remains also unclear.
CASE REPORT: We report in this publication the cases with different age brackets, who presented with various neurological symptoms such as repetitive seizures or anterograde amnesia. Cerebral CT-scan, cerebral MRI and anti onco-neural paraneoplastic antibodies were suggesting the diagnosis of paraneoplastic limbic encephalitis. Etiological exploration lead to the diagnosis of locally advanced small cell carcinoma of the lung. We started rapidly a curative protocol associating chemotherapy and sequential thoracic radiotherapy.
CONCLUSIONS: we insist on the diversity of the imaging findings, immunological analyses and outcome on treatment of this entity. Prognostic impact remains also unclear.