The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2025
A pilot study of apolipoprotein E genotype and associations with maternal lipid levels and small for gestational age outcomes in non-hypertensive pregnancies.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Wauer Cassandra, Thorlund-Diaz Carolina, Hakim Abbas, Meads Morgan, Castro-Martinez Anelizze, Parast Mana M, Laurent Louise C, Jacobs Marni B
Аннотация
OBJECTIVE: The aim of the present pilot study was to determine associations between maternal Apolipoprotein E (ApoE) genotype, lipid levels during pregnancy, fetal growth, and placental pathology.
METHODS: In this case-control study, serum samples from pregnant women without hypertension who delivered small-for-gestational age (SGA) infants (n = 50) were matched on gestational age at sample collection with non-SGA infants (n = 100). ApoE allele distributions and lipid levels were compared between cases and controls and among placental pathological findings.
RESULTS: No differences in ApoE genotypes were noted between groups. High density lipoprotein (HDL) cholesterol levels were higher in ε2 carriers versus ε3/ε3 and ε4 carriers (78.1 vs. 67.7 vs. 64.0 mg/dL, p < 0.01 and p < 0.001, respectively), and in SGA pregnancies (73.2 vs 65.1 mg/dL, p = 0.003).
CONCLUSION: Findings suggest increased HDL in pregnancy may be associated with the ε2 allele and decreased fetal growth. These findings provide a useful starting point for further research and should be explored in larger population-based studies.
METHODS: In this case-control study, serum samples from pregnant women without hypertension who delivered small-for-gestational age (SGA) infants (n = 50) were matched on gestational age at sample collection with non-SGA infants (n = 100). ApoE allele distributions and lipid levels were compared between cases and controls and among placental pathological findings.
RESULTS: No differences in ApoE genotypes were noted between groups. High density lipoprotein (HDL) cholesterol levels were higher in ε2 carriers versus ε3/ε3 and ε4 carriers (78.1 vs. 67.7 vs. 64.0 mg/dL, p < 0.01 and p < 0.001, respectively), and in SGA pregnancies (73.2 vs 65.1 mg/dL, p = 0.003).
CONCLUSION: Findings suggest increased HDL in pregnancy may be associated with the ε2 allele and decreased fetal growth. These findings provide a useful starting point for further research and should be explored in larger population-based studies.