Медицинская библиотека · International journal of clinical practice · 2023

Epidemiology and Association Rules Analysis for Pulmonary Tuberculosis Cases with Extrapulmonary Tuberculosis from Age and Gender Perspective: A Large-Scale Retrospective Multicenter Observational Study in China.

Kang Wanli, Yu Jiajia, Liang Chen, Wang Quanhong, Li Liang, Du Jian, Chen Hongyan, Liu Jianxiong, Ma Jinshan, Li Mingwu, Qin Jingmin, Shu Wei, Zong Peilan, Zhang Yi, Yan Xiaofeng, Yang Zhiyi, Mei Zaoxian, Deng Qunyi, Wang Pu, Han Wenge, Wu Meiying, Chen Ling, Zhao Xinguo, Tan Lei, Li Fujian, Zheng Chao, Liu Hongwei, Li Xinjie, A Ertai, Du Yingrong, Liu Fenglin, Cui Wenyu, Yang Song, Chen Xiaohong, Han Junfeng, Xie Qingyao, Feng Yanmei, Liu Wenyu, Tang Peijun, Zhang Jianyong, Zheng Jian, Chen Dawei, Yao Xiangyang, Ren Tong, Li Yan, Li Yuanyuan, Wu Lei, Song Qiang, Yang Mei, Zhang Jian, Liu Yuanyuan, Guo Shuliang, Yan Kun, Shen Xinghua, Lei Dan, Zhang Yanli, Li Youcai, Dong Yongkang, Tang Shenjie

Наблюдательное исследованиеМногоцентровое исследованиеСтатьяПеревод в очереди

Аннотация

BACKGROUND

Tuberculosis (TB), a multisystemic disease with protean presentation, remains a major global health problem. Although concurrent pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) cases are commonly observed clinically, knowledge regarding concurrent PTB-EPTB is limited. Here, a large-scale multicenter observational study conducted in China aimed to study the epidemiology of concurrent PTB-EPTB cases by diagnostically defining TB types and then implementing association rules analysis.

METHODS

The retrospective study was conducted at 21 hospitals in 15 provinces in China and included all inpatients with confirmed TB diagnoses admitted from Jan 2011 to Dec 2017. Association rules analysis was conducted for cases with concurrent PTB and various types of EPTB using the Apriori algorithm.

RESULTS

Evaluation of 438,979TB inpatients indicated PTB was the most commonly diagnosed (82.05%) followed by tuberculous pleurisy (23.62%). Concurrent PTB-EPTB was found in 129,422 cases (29.48%) of which tuberculous pleurisy was the most common concurrent EPTB type observed. The multivariable logistic regression models demonstrated that odds ratios of concurrent PTB-EPTB cases varied by gender and age group. For PTB cases with concurrent EPTB, the strongest association was found between PTB and concurrent bronchial tuberculosis (lift = 1.09). For EPTB cases with concurrent PTB, the strongest association was found between pharyngeal/laryngeal tuberculosis and concurrent PTB (lift = 1.11). Confidence and lift values of concurrent PTB-EPTB cases varied with gender and age.

CONCLUSIONS

Numerous concurrent PTB-EPTB case types were observed, with confidence and lift values varying with gender and age. Clinicians should screen for concurrent PTB-EPTB in order to improve treatment outcomes.

Для цитирования: Kang Wanli, Yu Jiajia, Liang Chen, Wang Quanhong, Li Liang, Du Jian, Chen Hongyan, Liu Jianxiong, Ma Jinshan, Li Mingwu, Qin Jingmin, Shu Wei, Zong Peilan, Zhang Yi, Yan Xiaofeng, Yang Zhiyi, Mei Zaoxian, Deng Qunyi, Wang Pu, Han Wenge, Wu Meiying, Chen Ling, Zhao Xinguo, Tan Lei, Li Fujian, Zheng Chao, Liu Hongwei, Li Xinjie, A Ertai, Du Yingrong, Liu Fenglin, Cui Wenyu, Yang Song, Chen Xiaohong, Han Junfeng, Xie Qingyao, Feng Yanmei, Liu Wenyu, Tang Peijun, Zhang Jianyong, Zheng Jian, Chen Dawei, Yao Xiangyang, Ren Tong, Li Yan, Li Yuanyuan, Wu Lei, Song Qiang, Yang Mei, Zhang Jian, Liu Yuanyuan, Guo Shuliang, Yan Kun, Shen Xinghua, Lei Dan, Zhang Yanli, Li Youcai, Dong Yongkang, Tang Shenjie. Epidemiology and Association Rules Analysis for Pulmonary Tuberculosis Cases with Extrapulmonary Tuberculosis from Age and Gender Perspective: A Large-Scale Retrospective Multicenter Observational Study in China.. International journal of clinical practice. 2023. DOI: 10.1155/2023/5562495.

Предметные рубрики MeSH

Humans Tuberculosis, Extrapulmonary Tuberculosis, Pleural Retrospective Studies Tuberculosis, Pulmonary China

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