Chromatin and epigenetic regulation in malignant tumors: A comprehensive review.

Epigenetics and chromatin biology have been two distinct research fields for many years. There is a close relationship between epigenetics and chromatin biochemistry, and the dynamic changes of chromatin serve as an important basis for epigenetic regulation. The relationship between epigenetics and chromatin is reflected in the dynamic changes and structural adjustments of chromatin. In this article, we focus on previously underappreciated chromatin remodeling proteins. This review summarizes the biological significance of chromatin remodeling complexes in malignancies, including the physiological role of chromatin remodeling complexes in normal cells and the dysregulation of chromatin remodeling complexes in malignant tumors with genetic, epigenetic, and gene expression alterations. It is important to explore the impact of chromatin remodeling complexes on cancer therapy, as predictors of drug response, targets of drug response, and contributors to therapeutic resistance.