[A 78-year-old woman suffering from diarrhea, abnormal fatigue, and depression].

A 78-year-old woman was admitted with diarrhea, abnormal fatigue, and depression. Routine diagnostic tests were to a large extent without pathological findings. Suppressed TSH was initially considered as subclinical hyperthyreosis because of substitution with L-thyroxin. The endocrinological diagnostics showed hypopituitarism because of an empty sella. After substitution with hydrocortisone and adapted L-thyroxin the patient recovered promptly. Diarrhea, abnormal fatigue, and depression might be hints for hypopituitarism with hypocortisolism.