Long-Term Quality of Life and Functional Outcome Analysis of Surgically Managed Central Neurocytoma Patients: Results of a Multicenter Study.
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Mallereau Charles-Henry, Virbel Guillaume, Pallud Johan, Severac François, Darlix Amélie, Mollevi Caroline, Lefevre Etienne, Peyre Matthieu, Roblot Paul, Nicolau Julien, Klotz Lubin, Sahler Yves, Le Van Tuan, Mezjan Insafe, Choucha Anis, Rivollier Maxime, Boulloud Christophe, Page Philippe, Picart Thiébaud, Metayer Thomas, Gavotto Amandine, Sellier Aurore, Claquin Johanna, Lemée Jean-Michel, Hamdan Noor, Todeschi Julien, Cebula Hélène, Chibbaro Salvatore, Bilger Mathias, Bauchet Fabienne, Zouaoui Sonia, Lhermitte Benoit, Figarella-Branger Dominique, Rigau Valérie, Trétarre Brigitte, Proust François, Noel Georges, Bauchet Luc, Club de Neuro-Oncologie de la Société Française de Neurochirurgie (CNO-SFNC)
Аннотация
METHODS: A multicenter retrospective study was conducted in 42 French neurosurgical centers. CN patients treated by surgical resection between 2006 and 2015 were included. We collected clinical, imaging, and surgical data. HRQoL was assessed by the European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire Core 30 (QLQ-C30) and its brain cancer-specific module (QLQ-BN20). Functional outcomes were evaluated by professional integration, return to driving, epileptic disease, and Karnofsky Performance Status (KPS) score.
RESULTS: Among 65 long-term postsurgery patients (median 11 years of follow-up), self-reported overall HRQoL score was 75.5 ± 18.4. Favorable cognitive, asthenia, and emotional scores were observed in 36.9%, 84.6%, and 72.3% of cases, respectively. Various degrees of professional integration were observed in 63.1%, driving resumption in 72.3%, and favorable KPS (>70) in 78.4% of cases; 33.8% of patients experienced daily epileptic treatment. The absence of acute postoperative hydrocephalus was significantly related with favorable functional outcomes for asthenia, professional integration, and global KPS.
CONCLUSION: CN patients treated by surgical resection showed generally high long-term HRQoL scores. However, cognitive outcomes remain severely affected with only one-third of patients achieving favorable results. Management of acute postoperative hydrocephalus represents a crucial factor for patients' functional prognosis and warrants clinicians' attention.