Current opinion in allergy and clinical immunology · 2023
Serum tryptase and drug hypersensitivity: why, how and what? A systematic review.
Систематический обзорСтатьяНазвание и аннотация: Перевод в очереди
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Klingebiel Caroline, Belhocine Wahib, Vitte Joana
Аннотация
PURPOSE OF REVIEW: Serum tryptase, a mast cell marker, provides clues for the mechanism, severity, and management of drug hypersensitivity induced by immunoglobulin E dependent or independent mast cell activation.
RECENT FINDINGS: The interpretation of serum tryptase levels has been challenged during the last 2 years by major advances in tryptase genetics and their rapid incorporation into clinical practice. On the contrary, new pathophysiological insight into nonmast cell-dependent immediate hypersensitivity has been gained.
SUMMARY: This review provides up-to-date information on the pathophysiology and recommended use and interpretation of tryptase in the context of drug hypersensitivity reactions as a function of their endotype.
RECENT FINDINGS: The interpretation of serum tryptase levels has been challenged during the last 2 years by major advances in tryptase genetics and their rapid incorporation into clinical practice. On the contrary, new pathophysiological insight into nonmast cell-dependent immediate hypersensitivity has been gained.
SUMMARY: This review provides up-to-date information on the pathophysiology and recommended use and interpretation of tryptase in the context of drug hypersensitivity reactions as a function of their endotype.