PRESUMED MITOMYCIN C-INDUCED RETINAL TOXICITY AFTER COMBINED CATARACT AND XEN GEL STENT SURGERY.

PURPOSE: To describe a case of presumed mitomycin C-induced retinal toxicity after combined cataract and XEN gel stent surgery.

METHODS

Observational case report.

RESULTS

A 66-year-old man presents with progressive vision loss (20/25 baseline to light-perception) after combined cataract and XEN gel stent surgery in the left eye. The patient received 0.15 mL of 0.4 mg/mL of mitomycin C via intratenon injection during the surgery. The patient reported severe eye pain after surgery, which gradually resolved over time. Upon examination at postoperative day 41, vessel attenuation, sclerotic vessels, and optic nerve pallor are observed without any retinal hemorrhaging. At postoperative day 55, visual acuity remains at light-perception with a flatline electroretinogram. Outcomes remain consistent at postoperative day 125.

CONCLUSION

Care should be taken to avoid intraocular mitomycin C, especially when administered via intratenon injection during combined cataract and XEN gel stent surgery.