Frontiers in medicine · 2026
Advantages of optical coherence tomography in assessing retinal astrocytic hamartomas in children with tuberous sclerosis complex.
СтатьяНазвание и аннотация: Перевод в очереди
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Dou Guorui, Zhou Ziyi, Sun Jiaxing, Zhang Zifeng, Wang Chunyan, Sun Dongjie, Zhu Jinting, Zhu Yanni, Zhang Hao, Wang Qihua, Li Manhong, Deng Yanchun, Wang Yusheng
Аннотация
PURPOSE: Retinal astrocytic hamartomas (RAHs) are benign tumors that are mostly associated with a rare systemic disorder called tuberous sclerosis complex (TSC). In the clinical diagnosis of TSC, RAH has been recognized as a major feature that supports a definite diagnosis. Here, 60 patients (120 eyes) with TSC underwent a complete ophthalmologic examination and multimodality imaging using fundus photographs, spectral-domain optical coherence tomography (SD-OCT), and infrared images.
METHODS: Admission SD-OCT data were retrieved and utilized for analysis. Receiver operating characteristic (ROC) curve analysis was performed to calculate the cutoff value.
RESULTS: A total of 117 hamartomas were detected in 45 patients, with a mean age of 12 years. On OCT imaging, RAHs appeared as gentle or protruding lesions of varying heights (mean thickness 314 mm, ranging between 71 and 974 mm).
CONCLUSION: For RAHs that could not be detected on fundus photographs or by ophthalmoscopy, OCT demonstrated excellent capability in revealing these lesions, particularly smaller tumors (MT < 271 mm). These results suggest that OCT can improve the detection of hamartomas and contribute to the diagnosis of TSC.
METHODS: Admission SD-OCT data were retrieved and utilized for analysis. Receiver operating characteristic (ROC) curve analysis was performed to calculate the cutoff value.
RESULTS: A total of 117 hamartomas were detected in 45 patients, with a mean age of 12 years. On OCT imaging, RAHs appeared as gentle or protruding lesions of varying heights (mean thickness 314 mm, ranging between 71 and 974 mm).
CONCLUSION: For RAHs that could not be detected on fundus photographs or by ophthalmoscopy, OCT demonstrated excellent capability in revealing these lesions, particularly smaller tumors (MT < 271 mm). These results suggest that OCT can improve the detection of hamartomas and contribute to the diagnosis of TSC.