Flumethasone-salicylic acid cream effectively flattened verrucous epidermal nevus: a case report.

OBJECTIVES

To assess the efficacy and safety of topical compound flumethasone pivalate-salicylic acid cream for verrucous epidermal nevus (VEN), a benign keratinocytic hamartoma with limited current treatment options.

METHODS

A 25-year-old male with 20-year VEN (right buttock/lower limb plaques) was treated with the compound cream (0.2 mg flumethasone pivalate + 30 mg salicylic acid/gram) twice daily for over 2 months, followed by 14-week follow-up.

RESULTS

Lesions showed progressive thinning, significantly reduced hyperpigmentation, and no adverse events. The Dermatology Life Quality Index score improved from 13 to 3, with no recurrence at follow-up.

CONCLUSIONS

Topical compound flumethasone pivalate-salicylic acid cream is effective and safe for VEN, potentially via inhibiting abnormal keratinocyte proliferation, serving as a practical topical option.