The Journal of hospital infection · 2025
Across time and space: phylogenetic analysis of carbapenem-resistant Acinetobacter baumannii in a network of general and convalescent hospitals.
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Lui E T L, Li C, Lee A L H, Sapugahawatte D N, Lee W S, Chiu G C S, Cheung I Y Y, Chow V C Y, Ip M
Аннотация
INTRODUCTION: Carbapenem-resistant Acinetobacter baumannii (CRAB) is a major threat to public health and is a common cause of nosocomial outbreaks.
AIM: To describe the genetic epidemiology of CRAB from both clinical and hospital environments in a network of hospitals in Hong Kong.
METHODS: A collection of 185 CRAB strains from patients (N = 143) and nosocomial environments (N = 42) from the period 2012 to 2024 underwent whole-genome sequencing to investigate the phylogenetic relatedness, virulence genes, antibiotic resistance genes and possible lineages of the strains that caused nosocomial outbreaks. Clinical information and antibiotic susceptibility test reports were retrieved from electronic medical records. Time and spatial distribution of the strains was assessed.
FINDINGS: The dominant sequence type of CRAB was ST2, accounting for 137 of 185 isolates (74.1%). It was followed by ST195 (N = 17, 9.2%) and ST49 (N = 16, 8.6%). All isolates carried the nreB gene that enhances environmental survival. Carriage of virulence factor genes was grossly similar between environmental and human isolates. Significantly more environmental isolates carried antimicrobial resistant genes conferring resistance to sulbactam-durlobactam, aminoglycosides and macrolides. Dissemination of CRAB across time and space in the regional network of hospitals was observed.
CONCLUSION: ST2 was the commonest sequence type in CRAB across clinical and nosocomial environment isolates of the entire hospital network, linking sporadic cases and clusters across different hospitals spanning over 10 years.
AIM: To describe the genetic epidemiology of CRAB from both clinical and hospital environments in a network of hospitals in Hong Kong.
METHODS: A collection of 185 CRAB strains from patients (N = 143) and nosocomial environments (N = 42) from the period 2012 to 2024 underwent whole-genome sequencing to investigate the phylogenetic relatedness, virulence genes, antibiotic resistance genes and possible lineages of the strains that caused nosocomial outbreaks. Clinical information and antibiotic susceptibility test reports were retrieved from electronic medical records. Time and spatial distribution of the strains was assessed.
FINDINGS: The dominant sequence type of CRAB was ST2, accounting for 137 of 185 isolates (74.1%). It was followed by ST195 (N = 17, 9.2%) and ST49 (N = 16, 8.6%). All isolates carried the nreB gene that enhances environmental survival. Carriage of virulence factor genes was grossly similar between environmental and human isolates. Significantly more environmental isolates carried antimicrobial resistant genes conferring resistance to sulbactam-durlobactam, aminoglycosides and macrolides. Dissemination of CRAB across time and space in the regional network of hospitals was observed.
CONCLUSION: ST2 was the commonest sequence type in CRAB across clinical and nosocomial environment isolates of the entire hospital network, linking sporadic cases and clusters across different hospitals spanning over 10 years.