[Not Available].

Crack use is increasing throughout Europe, particularly among socially marginalized groups in urban areas. Current pharmacological treatments for cocaine use disorder show limited efficacy. Cocaine-assisted treatment, modeled on heroin-assisted approaches, may offer a harm-reduction alternative. It combines medical supervision, controlled dosing, and better alignment with user preferences. Three administration routes are discussed: pharmaceutical-grade powder, user-prepared crack, or ready-to-use inhalable form. Such a strategy could reduce health risks, improve treatment adherence, and support structured care by tailoring the formulation and pharmacokinetics to different treatment phases.