Research in nursing & health · 2007
High-density lipoprotein prevents organ damage in endotoxemia.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Lee Ru-Ping, Lin Nien-Tsung, Chao Yann-Fen Chiou, Lin Chia-Chin, Harn Horng-Jyh, Chen Hsing-I
Аннотация
High-density lipoprotein (HDL) may decrease organ injury in sepsis. This study was designed using an animal model to mimic people who had a high HDL level and to test HDL effects on preventing organ damage in endotoxemia. Endotoxemia was induced by an infusion of lipopolysac-charide (LPS) after HDL or LDL administration. Levels of blood biochemical substances, nitrate/nitrite, and TNF-alpha in sera were measured. Pathological examinations were performed 72 hours after LPS infusion. HDL decreased the endotoxin-induced elevation of AST, ALT, BUN, creatinine, LDH, CPK, nitrate/nitrite, and TNF-alpha. On histological examination, neutrophil infiltration was lower in the HDL group. HDL had a significant effect in preventing endotoxin-induced organ damage.
Предметные рубрики MeSH
Alanine TransaminaseAnalysis of VarianceAnimalsAspartate AminotransferasesBlood PressureBlood Urea NitrogenCreatinineDisease Models, AnimalDrug Evaluation, PreclinicalEndotoxemiaHeart RateInfusions, IntravenousKlebsiella pneumoniaeL-Lactate DehydrogenaseLipopolysaccharidesLipoproteins, HDLLipoproteins, LDLMaleNitratesNitritesRatsRats, Inbred WKYTumor Necrosis Factor-alpha