Neoplasia in the vagina following hysterectomy for dysplasia or carcinoma in situ of the uterine cervix.

With a view to establishing some of the factors responsible for an increased risk of neoplasia in the vagina following primary hysterectomy for dysplasia or carcinoma in situ of the cervix, 63 surgical specimens from patients with subsequent neoplasia in the vagina have been compared with specimens from 40 patients without subsequent neoplasia. We found the frequency of neoplasia in the vagina to be greater when dysplasia or carcinoma in situ could be demonstrated in the vaginal margin. Neither the degree of endocervical glandular involvement, the number of mitoses, nor the inflammatory response of the connective tissue appeared to be significant in this respect. No significant connection was found between the severity of the preinvasive lesion of the cervix and the subsequent neoplasia in the vagina.