Diagnosis of chlamydial infection in the female urogenital tract, and treatment with doxycycline.

Microbiologic diagnostic tests (comprising phase-contrast microscopy, fungal cultures, staining cytology, and immunofluorescence microscopy with monoclonal antibodies against Chlamydia trachomatis) were performed in 100 women with recurrent urogenital infections. The incidence and localization of Chlamydia trachomatis are reported. The therapeutic efficacy of systemic treatment with doxycycline in this group was evaluated. All of the 25 patients in whom treatment and treatment results could be supervised reported marked or complete relief of symptoms after ten days of treatment with 200 mg/day of doxycycline. All clinical findings were normal, and immunofluorescence microscopy showed that the microorganisms were eradicated in all patients. Doxycycline was well tolerated, with only two patients reporting mild abdominal pain, which did not require termination of treatment.