Molecular psychiatry · 2019
A major role for common genetic variation in anxiety disorders.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Purves Kirstin L, Coleman Jonathan R I, Meier Sandra M, Rayner Christopher, Davis Katrina A S, Cheesman Rosa, Bækvad-Hansen Marie, Børglum Anders D, Wan Cho Shing, Jürgen Deckert J, Gaspar Héléna A, Bybjerg-Grauholm Jonas, Hettema John M, Hotopf Matthew, Hougaard David, Hübel Christopher, Kan Carol, McIntosh Andrew M, Mors Ole, Bo Mortensen Preben, Nordentoft Merete, Werge Thomas, Nicodemus Kristin K, Mattheisen Manuel, Breen Gerome, Eley Thalia C
Аннотация
Anxiety disorders are common, complex psychiatric disorders with twin heritabilities of 30-60%. We conducted a genome-wide association study of Lifetime Anxiety Disorder (ncase = 25 453, ncontrol = 58 113) and an additional analysis of Current Anxiety Symptoms (ncase = 19 012, ncontrol = 58 113). The liability scale common variant heritability estimate for Lifetime Anxiety Disorder was 26%, and for Current Anxiety Symptoms was 31%. Five novel genome-wide significant loci were identified including an intergenic region on chromosome 9 that has previously been associated with neuroticism, and a locus overlapping the BDNF receptor gene, NTRK2. Anxiety showed significant positive genetic correlations with depression and insomnia as well as coronary artery disease, mirroring findings from epidemiological studies. We conclude that common genetic variation accounts for a substantive proportion of the genetic architecture underlying anxiety.