Fertility and sterility · 1998
Triplet pregnancy with acardius acranius after preimplantation diagnosis.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Schild R L, Plath H, Födisch H J, Bartmann P, Hansmann M
Аннотация
OBJECTIVE: To report the first case of fetal malformation after preimplantation diagnosis for Duchenne muscular dystrophy (DMD).
DESIGN: Case report.
SETTING: Perinatal center in a university hospital.
PATIENT(S): A conductor for DMD in her third pregnancy.
INTERVENTION(S): Preimplantation diagnosis was performed in an outside hospital. In our center, a dichorionic triplet pregnancy with acardius acranius was diagnosed. The anastomosis between the "pump"-twin and the fetus with acardius was embolized with histoacryl to prevent worsening cardiac insufficiency of the "pump"-twin.
MAIN OUTCOME MEASURE(S): Pregnancy outcome.
RESULT(S): The anastomosis between the "pump"-twin and the fetus with acardius was occluded successfully. Premature preterm rupture of membranes led to rapid labor and delivery at 24 + 5 weeks' gestation. The smaller girl died of severe hyaline membrane disease, whereas the other infant had no major clinical problems and has developed well.
CONCLUSION(S): There might be an association between embryo biopsy and fetal malformations. The setting up of a birth register after embryo biopsy is strongly recommended.
DESIGN: Case report.
SETTING: Perinatal center in a university hospital.
PATIENT(S): A conductor for DMD in her third pregnancy.
INTERVENTION(S): Preimplantation diagnosis was performed in an outside hospital. In our center, a dichorionic triplet pregnancy with acardius acranius was diagnosed. The anastomosis between the "pump"-twin and the fetus with acardius was embolized with histoacryl to prevent worsening cardiac insufficiency of the "pump"-twin.
MAIN OUTCOME MEASURE(S): Pregnancy outcome.
RESULT(S): The anastomosis between the "pump"-twin and the fetus with acardius was occluded successfully. Premature preterm rupture of membranes led to rapid labor and delivery at 24 + 5 weeks' gestation. The smaller girl died of severe hyaline membrane disease, whereas the other infant had no major clinical problems and has developed well.
CONCLUSION(S): There might be an association between embryo biopsy and fetal malformations. The setting up of a birth register after embryo biopsy is strongly recommended.