International journal of paleopathology · 2021
Rare cases of rare diseases: Re-examining early 20th century cases of anencephaly from the collection of the Moscow State University, Russia.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Berezina N, Buzhilova A
Аннотация
OBJECTIVE: Documented cases of anencephaly were used to increase differential criteria of this rare disease.
MATERIAL: Two skulls from a 20th-century documented medical collection at the Moscow State University diagnosed with anencephaly.
METHODS: The skulls were evaluated based on macroscopic qualitative and quantitative morphological signs and X-ray analyses.
RESULTS: Metric values and morphological features differ between the two cases of anencephaly noted in the collection and the published data based on normal fetal and neonatal remains.
CONCLUSIONS: Analyses of medical collections helps to increase the number of diagnostic criteria for recognition and diagnosis of anencephaly in archaeological skeletons.
SIGNIFICANCE: Improvement in the recognition of skeletal alterations associated with anencephaly is key towards improving our understanding of rare diseases in the past.
LIMITATIONS: The fragility of skeletal elements of fetal and neonate individuals can complicate thorough analyses.
SUGGESTIONS FOR FURTHER RESEARCH: Continue to identify cases of anencephaly cases in medical collections and in archaeological contexts.
MATERIAL: Two skulls from a 20th-century documented medical collection at the Moscow State University diagnosed with anencephaly.
METHODS: The skulls were evaluated based on macroscopic qualitative and quantitative morphological signs and X-ray analyses.
RESULTS: Metric values and morphological features differ between the two cases of anencephaly noted in the collection and the published data based on normal fetal and neonatal remains.
CONCLUSIONS: Analyses of medical collections helps to increase the number of diagnostic criteria for recognition and diagnosis of anencephaly in archaeological skeletons.
SIGNIFICANCE: Improvement in the recognition of skeletal alterations associated with anencephaly is key towards improving our understanding of rare diseases in the past.
LIMITATIONS: The fragility of skeletal elements of fetal and neonate individuals can complicate thorough analyses.
SUGGESTIONS FOR FURTHER RESEARCH: Continue to identify cases of anencephaly cases in medical collections and in archaeological contexts.