Journal of perinatology : official journal of the California Perinatal Association · 2025
Proteinuria in preterm neonates: influence of fetal growth restriction.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Sehgal Arvind, Levins Criona, Yeomans Emma, Lu Zhong, Metz David
Аннотация
OBJECTIVE: To compare proteinuria in preterm neonates with fetal growth restriction-small for gestational age (FGR-SGA) against equally preterm but appropriate for gestational age (AGA) neonates.
STUDY DESIGN: Prospective, observational cohort study.
RESULTS: Eighteen FGR-SGA neonates were compared with 18 AGA neonates (gestation; 29 ± 1 vs 29 ± 2 weeks, P = 0.8). Urine total protein (median [interquartile range]) in FGR-SGA was higher 370 [323, 573] vs 255 [193, 453] mg/L in AGA, P = 0.017 at first assessment (week one) and 565 [445, 743] vs 225 [135, 458] mg/L, P = 0.0011 at second assessment (week four). Urine protein creatinine ratio was 393 [250, 445] in FGR-SGA vs 227 [163, 367] mg/mmol in AGA, P = 0.029 at first assessment and 444 [368, 699] vs 240 [199, 411] mg/mmol, P = 0.0014 at second assessment. Mean blood pressure was higher in FGR-SGA group & directly correlated with proteinuria.
CONCLUSIONS: Increased proteinuria in FGR-SGA suggests reduced nephron endowment and hyper-filtration.
STUDY DESIGN: Prospective, observational cohort study.
RESULTS: Eighteen FGR-SGA neonates were compared with 18 AGA neonates (gestation; 29 ± 1 vs 29 ± 2 weeks, P = 0.8). Urine total protein (median [interquartile range]) in FGR-SGA was higher 370 [323, 573] vs 255 [193, 453] mg/L in AGA, P = 0.017 at first assessment (week one) and 565 [445, 743] vs 225 [135, 458] mg/L, P = 0.0011 at second assessment (week four). Urine protein creatinine ratio was 393 [250, 445] in FGR-SGA vs 227 [163, 367] mg/mmol in AGA, P = 0.029 at first assessment and 444 [368, 699] vs 240 [199, 411] mg/mmol, P = 0.0014 at second assessment. Mean blood pressure was higher in FGR-SGA group & directly correlated with proteinuria.
CONCLUSIONS: Increased proteinuria in FGR-SGA suggests reduced nephron endowment and hyper-filtration.