Oral surgery, oral medicine, oral pathology and oral radiology · 2013
Bisphosphonate related osteonecrosis of the jaws: clinico-pathological investigation and histomorphometric analysis.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Anavi-Lev Karen, Anavi Yakir, Chaushu Gavriel, Alon Dror M, Gal Gavriel, Kaplan Ilana
Аннотация
OBJECTIVES: Clinico-pathological evaluation of bisphosphonate (BP)-related osteonecrosis of jaws, comparison between oral (PO) and intravenous (IV) BPs and histomorphometric analysis of associated actinomyces.
STUDY DESIGN: Retrospective clinical and histomorphometric analysis. Data on background, clinical, treatment and follow-up were analyzed. Actinomyces colonies were identified by typical filamentous colony morphology, Gram, and PAS stains. Colony density and relative colony surface area were measured.
RESULTS: Fifty-two patients were included, 37 (71.2%) IV, 15 (28.8%) PO BPs. with a mean duration of 2.33 and, 4.33 years respectively. One hundred percent of cases exhibited actinomyces colonization. The relative colony surface area was significantly higher in PO treatment (P = .024), with no differences in density, healing time or antibiotic treatment periods. High frequency of diabetes mellitus (60% PO cases) and corticosteroid treatment (25% of cases) were recorded.
CONCLUSION: Infection with actinomyces is a common denominator in BP-related osteonecrosis of the jaws (BRONJ), regardless of administration route. Diabetes and corticosteroid treatment seem to be important contributing factors for BRONJ.
STUDY DESIGN: Retrospective clinical and histomorphometric analysis. Data on background, clinical, treatment and follow-up were analyzed. Actinomyces colonies were identified by typical filamentous colony morphology, Gram, and PAS stains. Colony density and relative colony surface area were measured.
RESULTS: Fifty-two patients were included, 37 (71.2%) IV, 15 (28.8%) PO BPs. with a mean duration of 2.33 and, 4.33 years respectively. One hundred percent of cases exhibited actinomyces colonization. The relative colony surface area was significantly higher in PO treatment (P = .024), with no differences in density, healing time or antibiotic treatment periods. High frequency of diabetes mellitus (60% PO cases) and corticosteroid treatment (25% of cases) were recorded.
CONCLUSION: Infection with actinomyces is a common denominator in BP-related osteonecrosis of the jaws (BRONJ), regardless of administration route. Diabetes and corticosteroid treatment seem to be important contributing factors for BRONJ.
Предметные рубрики MeSH
ActinomycesActinomycosisAdministration, IntravenousAdministration, OralAdrenal Cortex HormonesAdultAgedAged, 80 and overAnti-Bacterial AgentsAntineoplastic AgentsBacterial LoadBisphosphonate-Associated Osteonecrosis of the JawBreast NeoplasmsDiabetes ComplicationsDiphosphonatesFemaleFollow-Up StudiesHumansIsraelMaleMiddle AgedMultiple MyelomaOsteomyelitisOsteoporosisProstatic NeoplasmsRetrospective StudiesRisk FactorsTime FactorsWound Healing