The Role of Medical Therapy in Hypertrophic Cardiomyopathy: An Updated Review.

This review highlights recent advances in hypertrophic cardiomyopathy (HCM) treatment, focusing on how to effectively implement both traditional and novel pharmacologic strategies in clinical practice. Traditional medications like beta-blockers and calcium channel blockers continue to play a critical role. However, new treatments, such as cardiac myosin inhibitors, provide an innovative approach for relieving symptoms, especially in obstructive HCM cases. Emerging therapies, including sodium-glucose cotransporter 2 inhibitors, sacubitril/valsartan, and ninerafaxstat, show promising benefits. Proper management of related conditions such as atrial fibrillation and heart failure is also essential. A comprehensive approach that considers individual patient characteristics and the specific subtype of HCM is essential for achieving optimal outcomes.